Authors: Nursel Türkmen Bülent Eren Recep Fedakar Semra Akgöz Nil Çomunoğlu
Publish Date: 2008/02/20
Volume: 25, Issue: 2, Pages: 123-132
Abstract
The toxicity of methanol is as a result of its metabolites formaldehyde and formic acid Formic acid induces severe metabolic acidosis causing death and is the primary agent responsible for ocular toxicity Glial fibrillary acidic protein GFAP immunostaining is the most commonly used method for examining astrocyte proliferation and hypertrophy after various central nervous system injuries The antigen CD34 is expressed widely on vascular endothelium including that of the central nervous system and high endothelial venulesThere was a positive correlation between the GFAP and CD34 intensity of staining scores in the methanolexposed group P=0711 P=0010 Furthermore there was also a positive correlation between the brain putamen and optic nerve head GFAP extent of staining in the methanolexposed group P=0720 P=0008 A statistically significant difference was found between the methanolexposed group and the control group optic nerve CD34 intensity scores P=0014 but no significant difference was found between optic nerve CD34 and GFAP extent scores P=005The study revealed that methanol affects brain putamen and the optic nerve selectively We detected a positive significant correlation between brain and optic nerve GFAP expression CD34 expression was markedly decreased by the toxic effects of methanol
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