Biomarkers for renal disease in childhood

Authors: Lena Das Hermine I Brunner

Publish Date: 2009/07/21

Volume: 11, Issue: 3, Pages: 218-225

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Abstract

A kidney biopsy is currently required to diagnose lupus nephritis LN Invasiveness related to kidney biopsies however makes it a prohibitive approach in daily clinical practice for the assessment of LNrelated activity and damage The lack of accurate LN biomarkers inhibits effective testing of new less toxic medications Research in LN biomarkers involves two principal methods 1 the candidate biomarker approach that tests molecules known to be involved in LN pathogenesis and 2 broadbased biomarkerscreening techniques These methods suggest that the following may all be potent LN biomarkers CCL2 chemokine CC motif ligand 2 also known as MCP1 monocyte chemotactic protein1 CCL5 chemokine CC motif ligand 5 also known as RANTES regulated on activation normal T expressed and secreted and CX3CL1chemokine CX3C motif ligand 1 also known as fractalkine IP10 interferoninducible protein 10 also known as chemokine CXC motif ligand 10 neutrophil gelatinase associate lipocalin hepcidin adiponectin transferrin ceruloplasmin lipocalinlike prostaglandin synthetaseD and orosomucoid

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