Neonatal effects of maternal antiphospholipid synd

Authors: Angela Tincani Chiara Biasini Rebaioli Laura Andreoli Andrea Lojacono Mario Motta

Publish Date: 2009/02/04

Volume: 11, Issue: 1, Pages: 70-76

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Abstract

Antiphospholipid antibodies aPL can impair the physiologic development of a fetus during pregnancy not only by causing thrombosis of the placental vessels but also by directly binding throphoblast cells and modifying their functions Consequently the presence of aPL in pregnant women is linked to an increased rate of pregnancy complications These include recurrent early miscarriages late fetal losses and hypertensive disorders of gestation In this clinical setting preeclampsia is usually early and severe and can be complicated by the syndrome of hemolysis elevated liver enzymes and low platelet count HELLP syndrome The close association between aPL and obstetric pathology supports the inclusion of these manifestations in the clinical classification criteria of antiphospholipid syndrome About 30 of children born to mothers with aPL passively acquire these autoantibodies fortunately the occurrence of thrombosis seems extremely rare in these babies The prospective ongoing studies of children born to antiphospholipid syndrome patients reassure us about their general good health however some data suggest that learning difficulties might occur possibly related to in utero exposure to aPL

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