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Title of Journal: Angiogenesis

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Abbravation: Angiogenesis

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Springer Netherlands

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DOI

10.1002/jemt.1070200312

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1573-7209

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Transplantation of sendai viral angiopoietin1mod

Authors: Wenhua Piao Huishan Wang Makoto Inoue Mamoru Hasegawa Hirofumi Hamada Jianhua Huang
Publish Date: 2010/05/11
Volume: 13, Issue: 3, Pages: 203-210
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Abstract

Sendai viral vector SeV is emerging as a promising vector for gene therapy However little information is available regarding the combination of SeVmediated gene and mesenchymal stem cell MSC therapy in dealing with ischemic diseases In this study we infected SeV to the MSCs in vitro and injected MSCs modified with SeV harboring human angiopoietin1 gene SeVhAng1 into the ischemic limb of rats in vivo We found SeV had high transductive efficiency to the MSCs Both MSCs and SeVhAng1modified MSCs improved the blood flow recovery and increased the capillary density of the ischemic limb compared with the control However in contrast to MSCs SeVhAng1modified MSCs had a better improvement of blood flow recovery in the ischemic limb We further found the ischemic limb injected with SeVhAng1modified MSCs had strong expression of pAkt which improved survival of MSCs injected into the ischemic limb This indicated SeVhAng1 modification enhanced angiogenetic effect of MSCs by both angiogenesis and cell protection We conclude that SeVhAng1modified MSCs may serve as a more effective tool in dealing with ischemic limb diseaseThis work was partly supported by a grant to HH from the Ministry of Education Science Japan and a grant to HJ from National Natural Science Foundation of China 30960379 We thank Takeo Yamamoto for his technical assistance in vector construction

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