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Title of Journal: Angiogenesis

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Abbravation: Angiogenesis

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Springer Netherlands

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DOI

10.1007/s13340-013-0148-5

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ISSN

1573-7209

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Association of endothelial proliferation with the

Authors: Katarzyna Korybalska Ewelina SworaCwynar Joanna Łuczak Alina Kanikowska Natasza Czepulis Rafał Rutkowski Andrzej Bręborowicz Marian Grzymisławski Janusz Witowski
Publish Date: 2016/05/31
Volume: 19, Issue: 3, Pages: 407-419
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Abstract

Substantial weight loss through intense dietary regimens is thought to ameliorate endothelial dysfunction in obesity It is less clear whether similar improvements can be achieved with modest dietary interventions This study aimed to identify the parameters of endothelial cell status in obesity that are affected by mild calorie restrictionAnalysis of endothelial transcriptome suggested that the intervention could impact on endothelial cell growth Cell proliferation was measured with the MTT test and verified by 3Hthymidine incorporation The participants were categorized according to a change in proliferation over time Significant decrease in endothelial cell proliferation correlated with the extent of weight loss in men but not in women This effect corresponded with changes in serum levels of leptin and adiponectin but was not related to serum concentrations of several known angiogenic mediators VEGF MCP1 TSP1 MMP9 angiopoietin2

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