Authors: Keith A Cengel Eric S Diffenderfer Stephen Avery Ann R Kennedy James McDonough
Publish Date: 2010/08/20
Volume: 49, Issue: 4, Pages: 715-721
Abstract
As a part of the near solar system exploration program astronauts may receive significant total body proton radiation exposures during a solar particle event SPE In the Center for Acute Radiation Research CARR symptoms of the acute radiation sickness syndrome induced by conventional radiation are being compared to those induced by SPElike proton radiation to determine the relative biological effectiveness RBE of SPE protons In an SPE the astronaut’s whole body will be exposed to radiation consisting mainly of protons with energies below 50 MeV In addition to providing for a potentially higher RBE than conventional radiation the energy distribution for an SPE will produce a relatively inhomogeneous total body dose distribution with a significantly higher dose delivered to the skin and subcutaneous tissues than to the internal organs These factors make it difficult to use a 60Co standard for RBE comparisons in our experiments Here the novel concept of using megavoltage electron beam radiation to more accurately reproduce both the total dose and the dose distribution of SPE protons and make meaningful RBE comparisons between protons and conventional radiation is described In these studies Monte Carlo simulation was used to determine the dose distribution of electron beam radiation in small mammals such as mice and ferrets as well as large mammals such as pigs These studies will help to better define the topography of the timedosefractionation versus biological response landscape for astronaut exposure to an SPE
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