Boron neutron capture therapy BNCT for liver met

Authors: Emiliano C C Pozzi Verónica A Trivillin Lucas L Colombo Andrea Monti Hughes Silvia I Thorp Jorge E Cardoso Marcela A Garabalino Ana J Molinari Elisa M Heber Paula Curotto Marcelo Miller Maria E Itoiz Romina F Aromando David W Nigg Amanda E Schwint

Publish Date: 2013/09/29

Volume: 52, Issue: 4, Pages: 481-491

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Abstract

Boron neutron capture therapy BNCT was proposed for untreatable colorectal liver metastases Employing an experimental model of liver metastases in rats we recently demonstrated that BNCT mediated by boronophenylalanine BPABNCT at 13 Gy prescribed to tumor is therapeutically useful at 3week followup The aim of the present study was to evaluate dose–response at 5week followup based on retrospective dose assessment in individual rats BDIX rats were inoculated with syngeneic colon cancer cells DHD/K12/TRb Tumorbearing animals were divided into three groups BPABNCT n = 19 Beam only n = 8 and Sham n = 7 matched manipulation no treatment For each rat neutron flux was measured in situ and boron content was measured in a preirradiation blood sample for retrospective individual dose assessment For statistical analysis ANOVA individual data for the BPABNCT group were pooled according to absorbed tumor dose BPABNCT I 45–89 Gy and BPABNCT II 92–16 Gy At 5 weeks postirradiation the tumor surface area posttreatment/pretreatment ratio was 122 ± 66 for Sham 78 ± 41 for Beam only 44 ± 56 for BPABNCT I and 045 ± 020 for BPABNCT II tumor nodule weight was 750 ± 480 mg for Sham 960 ± 620 mg for Beam only 380 ± 720 mg for BPABNCT I and 73 ± 59 mg for BPABNCT II The BPABNCT II group exhibited statistically significant tumor control with no contributory liver toxicity Potential threshold doses for tumor response and significant tumor control were established at 61 and 92 Gy respectivelyThis study was supported in part by inkind contributions from the US Department of Energy through Idaho National Laboratory a grant from the National Agency for the Promotion of Science and Technology of Argentina ANPCyT and a grant from the National Research Council of Argentina CONICET The study sponsors were not involved in the study The authors are indebted to the expert maintenance radioprotection and operation teams of RA3

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