Journal Title
Title of Journal: Curr Cardiovasc Imaging Rep
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Abbravation: Current Cardiovascular Imaging Reports
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Publisher
Current Science Inc.
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Authors: Kulveer S Mankia Martina A McAteer Robin P Choudhury
Publish Date: 2010/11/26
Volume: 4, Issue: 1, Pages: 17-23
Abstract
MRI is well suited for imaging vascular disease as it provides excellent soft tissue contrast and spatial resolution of the vessel wall By generating potent contrast effects iron oxide particles further enhance the ability of MRI to deliver functional information in a range of vascular syndromes Larger microparticles of iron oxide MPIO generate sufficient contrast to enable detection of lowabundance vascular targets in vivo Ligandconjugated MPIO confer molecular specificity facilitating molecular imaging of a range of specific endovascular targets This review discusses the application of iron oxide particles in the molecular imaging of a variety of vascular syndromes In particular ligandconjugated MPIO have been used for targeted molecular imaging in experimental models of atherosclerosis thrombosis and tissue ischemia syndromes This provides a platform for vascular molecular imaging that could accelerate diagnosis characterize disease progression and measure response to treatment in a clinical setting
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