Normal Databases for the Relative Quantification o

Authors: Mathieu Rubeaux Yuan Xu Guido Germano Daniel S Berman Piotr J Slomka

Publish Date: 2016/06/30

Volume: 9, Issue: 8, Pages: 22-

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Abstract

Myocardial perfusion imaging MPI with SPECT is performed clinically worldwide to detect and monitor coronary artery disease CAD MPI allows an objective quantification of myocardial perfusion at stress and rest This established technique relies on normal databases to compare patient scans against reference normal limits In this review we aim to introduce the process of MPI quantification with normal databases and describe the associated perfusion quantitative measures that are usedNew equipment and new software reconstruction algorithms have been introduced which require the development of new normal limits The appearance and regional count variations of normal MPI scans may differ between these new scanners and standard Anger cameras Therefore these new systems may require the determination of new normal limits to achieve optimal accuracy in relative myocardial perfusion quantification Accurate diagnostic and prognostic results rivaling those obtained by expert readers can be obtained by this widely used techniqueThroughout this review we emphasize the importance of the normal databases and the need for specific databases relative to distinct imaging procedures Use of appropriate normal limits allows optimal quantification of MPI by taking into account subtle image differences due to the hardware and software used and the population studiedMR and YX declare that they have no conflicts of interest CedarsSinai Medical Center receives royalties for the quantitative assessment of function perfusion and viability a minority portion of which is distributed to some of the authors of this manuscript GG DSB and PJS PJS also reports grants from Siemens outside the submitted workAll reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards including the Helsinki declaration and its amendments institutional/national research committee standards and international/national/institutional guidelinesThis research was supported in part by grant R01HL089765 from the National Heart Lung and Blood Institute/National Institutes of Health NHLBI/NIH PI PJS Also YX is now affiliated with the School of Nursing University of California San Francisco CA

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