Toxicological Effects of Three Polybromodiphenyl E

Authors: L Mhadhbi J Fumega R Beiras

Publish Date: 2012/04/20

Volume: 223, Issue: 7, Pages: 4007-4016

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Abstract

Polybrominated diphenyl ethers PBDEs are highly persistent anthropogenic contaminants found in trace amounts in many environmental compartments far from their source areas posing a risk to aquatic ecosystems Our objective was to determine the relative toxicities of three BDEs BDE47 BDE99 and BDE154 on marine phytoplankton algae Isochrysis galbana For a highly sensitive endpoint the 72h inhibition of autotrophic growth rate was calculated according to standards methods Actual PBDE concentration was measured by GCMS and toxicity parameters were calculated on the basis of timeweighted mean actual concentrations No observable effect concentration NOEC values were 253 μg L−1 for BDE47 348 μg L−1 for BDE99 and 123 μg L−1 for BDE154 and LOEC values were 506 696 and 2460 μg L−1 for BDE47 BDE99 and BDE154 respectively The calculated IC10 the concentration inhibiting growth rate by 10  corresponded to 93 1278 and 546 μg L−1 for BDE47 BDE99 and BDE154 respectively The 50  inhibitions of growth rate IC50 values were 257 μg L−1 BDE47 300 μg L−1 BDE99 and 2437 μg L−1 BDE154 Therefore the acute toxicity of PBDEs decreases as the degree of bromination increases the order of toxicity is BDE47  BDE99  BDE154 Significant p  005 adverse effects were observed for all compounds at concentrations 15 μg L−1 Our results indicated that under laboratory conditions PBDEs inhibited the growth of marine phytoplankton at concentrations near 10 μg L−1 However further work is required to investigate longterm effects in these and other aquatic organismsThe authors gratefully acknowledge the cooperation of all the workers and personnel at the ECIMAT and Laboratory of Marine ecology We would like to express our warmest thanks to Ms Alexandra Barciela Pereira and Ms Nuria Trigo Sampedro for their technical assistance We extend our thanks to Sara Pérez and Diego Rial This study was financially supported by MAEPCI Ministry of Foreign Affairs Spain Ministry of Higher Education Scientific Research and Technology in Tunisia and Spanish Ministry of Science and Innovation MCINN through the research project ref CTM200910908 Environmental Quality Criteria for Marine Ecosystems ENVICRISYS

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