66 Polycystic Ovary Syndrome Implications of Ald

Authors: S Garelli C Fiore A Andrisani F Manganello S Cavaliere D Pellati D Faggian M Plebani G Ambrosini D Armanini

Publish Date: 2013/01/22

Volume: 15, Issue: 3, Pages: 241-241

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Abstract

Methods We enrolled 30 women 15 with PCOS and 15 healthy matched for age and BMI Rotterdam criteria were used for the diagnosis of PCOS None of the patients had hypertension or diabetes or were taking hormones and/or other medications which could affect the interpretation of the results All subjects underwent hormonal measurements at the days 7 14 and 21 of the cycle aldosterone plasma renin activity 17OHprogesterone testosterone androstenedione dehydroepiandrosterone sulfate Creactive protein IL6 serum sodium and potassiumResults Data were analysed considering the following groups a general groups comprehending all the patients together in the 3 phases of the cycle PCOS and controls b 2 subgroups subdividing the patients in relation to their values of progesterone P on the 21st day of the cycle the first group consisted of patients with pg value 10 nmol/l and the second group included patients with P10 nmol/l this cutoff was putatively considered a marker of ovulation Considering the general groups aldosterone level was significantly higher p 002 in PCOS women compared with healthy women in all the phases of the cycle Considering the two subgroups aldosterone was higher in nonovulating PCOS compared with nonovulating healthy women both in the estrogenic and luteal phases Progesterone levels between the two groups were not different in all the phases of the cycle Progesterone/aldosterone ratio was lower p002 in PCOS compared with healthy women in the estrogenic and luteal phaseConclusions The progesterone/aldosterone ratio can be considered a marker of aldosterone action An increase in progesterone level in the luteal phase can be considered a protective mechanism against aldosterone action being progesterone an antagonist at the level of mineralocorticoid receptors The progesterone/aldosterone ratio is lower in nonovulating PCOS patients than in controls both in the estrogenic and progestinic phases It is possible that chronic anovulation or oligoovulation is involved in the increased inflammatory action of aldosterone in PCOS due to reduced protection by endogenous progesterone

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