Metabolic syndrome and associated chronic kidney d

Authors: P Anil Kumar P Swathi Chitra G Bhanuprakash Reddy

Publish Date: 2013/09/15

Volume: 14, Issue: 3, Pages: 273-286

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Abstract

Lifestyle changes such as dietary habits sedentary life and consumption of energydense foods that have occurred over the years has led to an epidemic of abdominal obesity which in turn resulted in dramatic increase in the prevalence of metabolic syndrome MetS Different expert panels have provided various definitions for MetS to enable a clinical diagnosis and treatment of patients at risk of associated complications Obesity and obesity mediated MetS has been paralleled by escalation in the incidence of chronic kidney disease CKD A better understanding of the pathophysiology of MetS and identification of individuals with MetS early in the life course could be important for initiating interventions such as lifestyle modification and dietary restrictions that form the basis for prevention and treatment of MetS and related comorbidities including CKD This review is intended to provide a comprehensive summary of the evolution of definition of MetS and association of MetS with CKD In particular mechanism of obesity and diabetes mediated CKD and emerging dietary therapies for MetS associated CKD will be discussed

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