Skeletal muscle glucose metabolism and inflammatio

Authors: André Marette Ying Liu Gary Sweeney

Publish Date: 2014/10/19

Volume: 15, Issue: 4, Pages: 299-305

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Abstract

Insulin resistance and metabolic dysfunction in skeletal muscle play a major role in the development of the metabolic syndrome and type 2 diabetes Numerous mechanisms have been proposed to explain the pathophysiology of obesitylinked metabolic dysfunction and this review will focus on the contributing role of adiponectin and inflammation The beneficial effects of adiponectin on both insulin action and inflammation are now well documented and will be reviewed More recent work provided new insights into adiponectin signaling mechanisms The development of strategies to mimic adiponectin action holds promise that adiponectinbased compounds may translate into effective therapeutic applications We will also discussed the novel role of long chain ω3 PUFAderived resolution mediators which in addition to resolving inflammation can also exert glucoregulatory effects in models of obesity and insulin resistance We will focus on one resolution mediator protectin DX PDX which was recently shown to act as a muscle interleukin6 secretagogue PDX and its isomer PD1 also enhance adiponectin expression and action Ultimately it is via a better understanding the molecular mechanisms of action via which inflammation insulin resistance and metabolic dysfunction occur in skeletal muscle and also how they crosstalk with each other that we can generate new and improved therapies for obesitylinked metabolic complicationsRelated work in the authors laboratories is supported by operating grants from Canadian Diabetes Association AM GS Heart Stroke Foundation of Canada GS Canadian Institutes of Health Research AM GS GS also acknowledges support via a Career Investigator Award from Heart Stroke Fundation Ontario AM was supported by a CIHR/Pfizer Research Chair in the pathogenesis of insulin resistance and cardiovascular diseases

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