Authors: J V Pohlmeyer S L Waters L J Cummings
Publish Date: 2013/01/29
Volume: 75, Issue: 3, Pages: 393-427
Abstract
Motivated by experimental work Miller et al in Biomaterials 27102213–2221 2006 32112775–2785 2011 we investigate the effect of growth factor driven haptotaxis and proliferation in a perfusion tissue engineering bioreactor in which nutrientrich culture medium is perfused through a 2D porous scaffold impregnated with growth factor and seeded with cells We model these processes on the timescale of cell proliferation which typically is of the order of days While a quantitative representation of these phenomena requires more experimental data than is yet available qualitative agreement with preliminary experimental studies Miller et al in Biomaterials 27102213–2221 2006 is obtained and appears promising The ultimate goal of such modeling is to ascertain initial conditions growth factor distribution initial cell seeding etc that will lead to a final desired outcomeThis work is supported by Award No KUKC101304 made by King Abdullah University of Science and Technology KAUST The authors wish to thank Dr Lee Weiss and Dr Phil Campbell for use of experimental images included in this paper JP would like to thank Drs Treena Arinzeh Shahriar Afkami and Michael Siegel for much useful guidance with development and numerical solution of the model SLW is grateful to the ERSRC for funding in the form of an Advanced Research Fellowship
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