Authors: J Hastanin C Lenaerts K FleuryFrenette S Habraken
Publish Date: 2013/12/06
Volume: 9, Issue: 3, Pages: 519-526
Abstract
Surface plasmons resonance SPR architectures based on grating coupler/disperser combination is an attractive alternative for spectralbased biochemical sensing In this paper we investigate theoretically and experimentally a new concept where the plasmon coupling occurs through a thin film grating and sensing occurs via the first evanescent diffraction order in transmitive mode The surface plasmon wave excitation induces a peak in the wavelength as well as in the angular spectra of the detected first transmitted diffraction order Accordingly a change in SPR spectrum of the detected diffraction order can be used to quantify the amount of the target molecules immobilized on the sensor surface and therefore the concentration of these molecules in the analyte solution The developed sensor architecture is dedicated to droplet biochemical sensing and appears to be especially suitable for biosensor integration and miniaturization The presented sensor concept is perfectly suited for mass production of lowcost and reproducible SPR sensor chip for biochemical analysis The implemented setup gives access to multichannel biosensing with the potential for efficient internal referencing essential to achieve sufficiently high reproducibility and accuracy of the measurementsThis research is performed within the frame of the “PLASMOBIO” project from the INTERREG IV program involving a financial support from the European Union and the Walloon region 14 The authors thank IEMN of the University of Lille 1 France for the technical support in the grating structure fabrication
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