Journal Title
Title of Journal: Drug Deliv and Transl Res
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Abbravation: Drug Delivery and Translational Research
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Authors: Rajkumar Malayandi Phani Krishna Kondamudi P K Ruby Deepika Aggarwal
Publish Date: 2013/12/07
Volume: 4, Issue: 2, Pages: 187-202
Abstract
Colon targeted dosage forms have been extensively studied for the localized treatment of inflammatory bowel disease These dosage forms not only improve the therapeutic efficacy but also reduce the incidence of adverse drug reactions and hence improve the patient compliance However complex and highly variable gastro intestinal physiology limits the clinical success of these dosage forms Biopharmaceutical characteristics of these dosage forms play a key role in rapid formulation development and ensure the clinical success The complexity in product development and clinical success of colon targeted dosage forms are based on the biopharmaceutical characteristics such as physicochemical properties of drug substances pharmaceutical characteristics of dosage form physiological conditions and pharmacokinetic properties of drug substances as well as drug products Various in vitro and in vivo techniques have been employed in past to characterize the biopharmaceutical properties of colon targeted dosage forms This review focuses on the factors influencing the biopharmaceutical performances of the dosage forms in vitro characterization techniques and in vivo studies
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