Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Drug Deliv and Transl Res

Search In Journal Title:

Abbravation: Drug Delivery and Translational Research

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1002/xrs.1300140210

Search In DOI:

ISSN

2190-3948

Search In ISSN:
Search In Title Of Papers:

Preparation and characterization of metoprolol tar

Authors: Venkata Ramana Malipeddi Rajendra Awasthi Daniela Dal Molim Ghisleni Marina de Souza Braga Irene Satiko Kikuchi Terezinha de Jesus Andreoli Pinto Kamal Dua
Publish Date: 2016/09/27
Volume: 7, Issue: 1, Pages: 66-76
PDF Link

Abstract

The present study aimed to develop matrixtype transdermal drug delivery system TDDS of metoprolol tartrate using polyvinyl pyrrolidone PVP and polyvinyl alcohol PVA The transdermal films were evaluated for physical parameters Fourier transform infrared spectroscopy analysis FTIR differential scanning calorimetry DSC in vitro drug release in vitro skin permeability skin irritation test and stability studies The films were found to be tough nonsticky easily moldable and possess good tensile strength As the concentration of PVA was increased the tensile strength of the films was also increased Results of FTIR spectroscopy and DSC revealed the absence of any drugpolymer interactions In vitro release of metoprolol followed zeroorder kinetics and the mechanism of release was found to be diffusion rate controlled In vitro release studies of metoprolol using KesharyChein vertical diffusion cell indicated 655  drug was released in 24 h In vitro skin permeation of metoprolol transdermal films showed 5813  of the drug was released after 24 h In vitro skin permeation of metoprolol followed zeroorder kinetics in selected formulations The mechanism of release was found to be diffusion rate controlled In a 22day skin irritation test tested formulation of transdermal films did not exhibit any allergic reactions inflammation or contact dermatitis The transdermal films showed good stability in the 180day stability study It can be concluded that the TDDS of MPT can help in bypassing the firstpass effect and will provide patient improved compliance without sacrificing the therapeutic advantages of the drugsThe animal experimental protocol was approved by the Institutional Animal Ethical Committee The animals were handled as per the guidelines of the Committee for the Purpose of Control and Supervision on Experimental animals CPCSEA New Delhi India

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Solid lipid nanoparticles of amphotericin B (AmbiOnp): in vitro and in vivo assessment towards safe and effective oral treatment module
  2. Liposomally encapsulated CDC20 siRNA inhibits both solid melanoma tumor growth and spontaneous growth of intravenously injected melanoma cells on mouse lung
  3. Tocopheryl phosphate mixture (TPM) as a novel lipid-based transdermal drug delivery carrier: formulation and evaluation
  4. Biopharmaceutical considerations and characterizations in development of colon targeted dosage forms for inflammatory bowel disease
  5. Lidocaine permeation from a lidocaine NaCMC/gel microgel formulation in microneedle-pierced skin: vertical (depth averaged) and horizontal permeation profiles
  6. Intravitreal poly( l -lactide) microparticles sustain retinal and choroidal delivery of TG-0054, a hydrophilic drug intended for neovascular diseases
  7. Fluorescently labeled microbubbles for facilitating translational molecular ultrasound studies
  8. Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates—proof of concept for HIV mucosal pre-exposure prophylaxis
  9. Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging
Search Result: