Journal Title
Title of Journal: Drug Deliv and Transl Res
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Abbravation: Drug Delivery and Translational Research
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Authors: Venkata Ramana Malipeddi Rajendra Awasthi Daniela Dal Molim Ghisleni Marina de Souza Braga Irene Satiko Kikuchi Terezinha de Jesus Andreoli Pinto Kamal Dua
Publish Date: 2016/09/27
Volume: 7, Issue: 1, Pages: 66-76
Abstract
The present study aimed to develop matrixtype transdermal drug delivery system TDDS of metoprolol tartrate using polyvinyl pyrrolidone PVP and polyvinyl alcohol PVA The transdermal films were evaluated for physical parameters Fourier transform infrared spectroscopy analysis FTIR differential scanning calorimetry DSC in vitro drug release in vitro skin permeability skin irritation test and stability studies The films were found to be tough nonsticky easily moldable and possess good tensile strength As the concentration of PVA was increased the tensile strength of the films was also increased Results of FTIR spectroscopy and DSC revealed the absence of any drugpolymer interactions In vitro release of metoprolol followed zeroorder kinetics and the mechanism of release was found to be diffusion rate controlled In vitro release studies of metoprolol using KesharyChein vertical diffusion cell indicated 655 drug was released in 24 h In vitro skin permeation of metoprolol transdermal films showed 5813 of the drug was released after 24 h In vitro skin permeation of metoprolol followed zeroorder kinetics in selected formulations The mechanism of release was found to be diffusion rate controlled In a 22day skin irritation test tested formulation of transdermal films did not exhibit any allergic reactions inflammation or contact dermatitis The transdermal films showed good stability in the 180day stability study It can be concluded that the TDDS of MPT can help in bypassing the firstpass effect and will provide patient improved compliance without sacrificing the therapeutic advantages of the drugsThe animal experimental protocol was approved by the Institutional Animal Ethical Committee The animals were handled as per the guidelines of the Committee for the Purpose of Control and Supervision on Experimental animals CPCSEA New Delhi India
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