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Title of Journal: J Neurovirol

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Abbravation: Journal of NeuroVirology

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Springer US

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DOI

10.1007/978-1-4419-0851-3_411

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1538-2443

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Translational challenges in targeting latent HIV i

Authors: Carolina Garrido David M Margolis
Publish Date: 2014/07/25
Volume: 21, Issue: 3, Pages: 222-226
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Abstract

Too controversial to discuss only a short time ago achieving a cure for HIV infection has become a priority in HIV research However substantial challenges must be overcome Among key hurdles to be surmounted is the definition of a reliable validated model in which to test latency reversal agents LRAs as current primary cell models differ in their response to such agents Animal models such as the HIVinfected humanized BLT mouse and SIVinfected macaque will be essential to study LRAs and to quantify their effects in anatomic reservoirs Of several potential anatomic reservoirs the central nervous system presents a significant obstacle as it is known to harbor persistent HIV infection and is difficult to access for study and therapeutic intervention

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Other Papers In This Journal:
  1. Statistical analysis of PML incidences of natalizumab-treated patients from 2009 to 2016: outcomes after introduction of the Stratify JCV® DxSelect™ antibody assay
  2. Genome editing strategies: potential tools for eradicating HIV-1/AIDS
  3. Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining “symptomatic” versus “asymptomatic” HAND
  4. Central nervous system penetration effectiveness of antiretroviral drugs and neuropsychological impairment in the Ontario HIV Treatment Network Cohort Study
  5. HIV and aging
  6. The flavivirus dengue induces hypertrophy of white matter astrocytes
  7. Defining the roles for Vpr in HIV-1-associated neuropathogenesis
  8. Japanese encephalitis in a French traveler to Nepal
  9. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques
  10. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
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