Journal Title
Title of Journal: J Neurovirol
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Abbravation: Journal of NeuroVirology
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Authors: Adriana Carvalhal M John Gill Scott L Letendre Anita Rachlis Tsegaye Bekele Janet Raboud Ann Burchell Sean B Rourke and the Centre for Brain Health in HIV/AIDS
Publish Date: 2015/11/16
Volume: 22, Issue: 3, Pages: 349-357
Abstract
Since the introduction of combination antiretroviral therapy cART the incidence of severe HIVassociated neurocognitive impairment has declined significantly whereas the prevalence of the milder forms has increased Studies suggest that better distribution of cART drugs into the CNS may be important in reducing viral replication in the CNS and in reducing HIVrelated brain injury Correlates of neuropsychological NP performance were determined in 417 participants of the Ontario HIV Treatment Cohort Study OCS All participants were on three cART drugs for at least 90 days prior to assessment Multiple logistic and linear regression methods were used Most participants were Caucasian men with mean age of 47 years About two thirds had a nadir CD4+ Tcell count below 200 cells/μL and 92 had an undetectable plasma HIV viral load The median CNS penetration effectiveness CPE score was 7 Sixty percent of participants had neuropsychological impairment Higher CPE values significantly correlated with lower prevalence of impairment in bivariate and multivariate analyses In this crosssectional analysis of HIV+ adults who had a low prevalence of comorbidities and were taking threedrug cART regimens greater estimated distribution of cART drugs into the CNS was associated with better NP performanceThe Ontario HIV Treatment Network Cohort Study is funded by the Ontario Ministry of Health and LongTerm Care OHTN Chair in Biostatistics Public Health Ontario PHO Laboratories for providing the viral load testing The views and conclusion presented here are not necessarily those of PHO Preliminary results of this work was previously presented at the 19th Conference in Retrovirus and Opportunistic Infections CROI 2012 Paper 484––Seattle WA USA
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