Exercise Modalities and Endothelial Function A Sy

Authors: Ammar W Ashor Jose Lara Mario Siervo Carlos CelisMorales Clio Oggioni Djordje G Jakovljevic John C Mathers

Publish Date: 2014/10/04

Volume: 45, Issue: 2, Pages: 279-296

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Abstract

The aims of this systematic review and metaanalysis were to i investigate the effect of exercise modalities aerobic resistance or combined on FMD and ii determine which exercise and participant characteristics are most effective in improving FMDWe searched the MEDLINE Embase Cochrane Library and Scopus databases for studies that met the following criteria i randomized controlled trials of exercise with comparative nonexercise usual care or sedentary groups ii duration of exercise intervention ≥4 weeks iii age ≥18 years and iv EF measured by FMD before and after the intervention Weighted mean differences WMDs with 95  confidence interval were entered into a random effect model to estimate the pooled effect of the exercise interventionsAll exercise modalities enhanced EF significantly aerobic WMD 279 95  CI 212–345 p = 00001 resistance WMD 252 95  CI 111–393 p = 00001 and combined WMD 207 95  CI 070–344 p = 0003 A dose–response relationship was observed between aerobic exercise intensity and improvement in EF A 2 metabolic equivalents MET increase in absolute exercise intensity or a 10  increase in relative exercise intensity resulted in a 1  unit improvement in FMD There was a positive relationship between frequency of resistance exercise sessions and improvement in EF β 114 CI 016–212 p = 0027AA is funded by the Ministry of Higher Education and Scientific Research of Iraq JL and JCM acknowledge support from the LiveWell Programme a research project funded through a collaborative grant from the Lifelong Health and Wellbeing LLHW initiative managed by the Medical Research Council MRC Grant number G0900686 The authors have no potential conflicts of interest that are directly relevant to the content of this review

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