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Title of Journal: J Mol Evol

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Abbravation: Journal of Molecular Evolution

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Springer US

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1432-1432

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Compensatory Mutations Occur Within the Electrosta

Authors: Amrita Bhattacherjee Saurav Mallik Sudip Kundu
Publish Date: 2014/11/16
Volume: 80, Issue: 1, Pages: 10-12
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Abstract

A compensatory mutation CM counter balances lethal effects of a deleterious mutation DM ensuring the persistence of both through natural selection However little is known about the biological aspects of CMs those restore the structural alterations of proteins caused by slightly DMs Here by analyzing the evolution of the UDPglycosyltransferase 73B4 protein among monocotdicot plants we investigate the occurrence of CMs around slightly DMs in 3D space Our results illustrate that CMs exhibit significantly higher tendency to occur within the range of electrostatic interaction around the slightly DMs compared to occurring randomly in the protein


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