Journal Title
Title of Journal: Cardiovasc Drugs Ther
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Abbravation: Cardiovascular Drugs and Therapy
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Authors: Francisco J Chorro Irene del Canto Laia Brines Luis SuchMiquel Conrado Calvo Carlos Soler Germán Parra Manuel Zarzoso Isabel Trapero Álvaro Tormos Antonio Alberola Luis Such
Publish Date: 2015/07/03
Volume: 29, Issue: 3, Pages: 231-241
Abstract
Mechanical stretch is an arrhythmogenic factor found in situations of cardiac overload or dyssynchronic contraction Ranolazine is an antianginal agent that inhibits the late Na + current and has been shown to exert a protective effect against arrhythmias The present study aims to determine whether ranolazine modifies the electrophysiological responses induced by acute mechanical stretchThe ventricular fibrillation modifications induced by acute stretch were studied in Langendorffperfused rabbit hearts using epicardial multiple electrodes under control conditions n = 9 or during perfusion of the late Na + current blocker ranolazine 5 μM n = 9 Spectral and mapping techniques were used to establish the ventricular fibrillation dominant frequency the spectral concentration and the complexity of myocardial activation in three situations baseline stretch and poststretchRanolazine attenuated the increase in ventricular fibrillation dominant frequency produced by stretch 230 vs 404 control baseline =136 ± 26 Hz stretch = 191 ± 31 Hz p 00001 ranolazine baseline = 114 ± 18 Hz stretch =140 ± 24 Hz p 005 vs baseline p 0001 vs control During stretch ventricular fibrillation was less complex in the ranolazine than in the control series as evaluated by the lesser percentage of complex maps and the greater spectral concentration of ventricular fibrillation These changes were associated to an increase in the fifth percentile of VV intervals during ventricular fibrillation 50 ± 8 vs 38 ± 5 ms p 001 and in the wavelength of the activation 24 ± 03 vs 19 ± 02 cm p 0001 under ranolazine
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