Authors: Md Shakhawath Hossain X B Chen D J Bergstrom
Publish Date: 2015/02/15
Volume: 51, Issue: 10, Pages: 1493-1504
Abstract
Knowledge of the fluid flow and mass transfer over circular strands is fundamental to the cell culture of tissue scaffolds in bioreactors This paper presents a study on the simulation of fluid flow and mass transfer over the circular strands of a tissue scaffold by using the multiple relaxation time lattice Boltzmann method for the low Reynolds number regime with Re D = 001 and 01 respectively The mass transfer problem approximates the transport of a scalar nutrient from the bulk fluid to the strand surface such as is encountered in the flow through tissue scaffolds placed in bioreactors The circular geometry of the scaffold strand is treated and implemented by means of the interpolated bounceback boundary condition formulation Our simulation illustrates that the flow accelerates around the strand resulting in the maximum shear stress at the shoulder of the strand and that diffusion mass transfer plays the dominant role in the scalar transport The local Sherwood number varies significantly over the surface of the strand with a peak value located on the upstream surface Increasing the Schmidt number of the scalar and decreasing the blockage ratio results in higher mass transfer rates on the surface of the stand Overall the simulation results provide one with the insight into the fluid flow and mass transfer over the circular strands of a tissue scaffold in a bioreactor which would be impractical to obtain by experiments
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