Journal Title
Title of Journal: Abdom Radiol
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Abbravation: Abdominal Radiology
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Authors: Carlo N De Cecco Maria Ciolina Damiano Caruso Marco Rengo Balaji Ganeshan Felix G Meinel Daniela Musio Francesca De Felice Vincenzo Tombolini Andrea Laghi
Publish Date: 2016/04/07
Volume: 41, Issue: 9, Pages: 1728-1735
Abstract
12 consecutive patients 8 females 4 males 632 ± 134 years with rectal cancer were prospectively enrolled and underwent pretreatment 3T MRI Treatment protocol consisted of neoadjuvant CRT with oxaliplatin and 5fluorouracile Unenhanced T2weighted images TA kurtosis apparent diffusion coefficient ADC and pMRI parameters Ktrans Kep Ve IAUGC were quantified by manually delineating a region of interest around the tumor outline After CRT all patients underwent complete surgical resection and the surgical specimen served as the gold standard Receiver operating characteristic ROC curve analysis was performed to assess the discriminatory power of each quantitative parameter to predict complete responsePathological complete response pCR was reported in six patients and partial response PR in three patients Three patients were classified as nonresponders NR Pretreatment kurtosis was significantly lower in the pCR subgroup in comparison with PR + NR p = 01 Among ADC and pMRI parameters only Ve was significantly lower in the pCR subgroup compared with PR + NR p = 01 A significant negative correlation between kurtosis and ADC r = −0650 p = 022 was observed Pretreatment area under the ROC curves AUC to discriminate between pCR and PR + NR was significantly higher for kurtosis 0861 p = 001 and Ve 0861 p = 003 compared to all other parameters The optimal cutoff value for pretreatment kurtosis and Ve was ≤019 100 sensitivity 67 specificity and ≤0311 83 sensitivity 83 specificity respectivelyB Ganeshan is a director parttime employee and shareholder of Feedback Plc Cambridge England UK company that develops and markets the TexRAD texture analysis algorithm described in this manuscript The other authors declare that they have no conflict of interestAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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