Correlation between quantitative and semiquantitat

Authors: Rebecca A P Dijkhoff Monique Maas Milou H Martens Nikolaos Papanikolaou Doenja M J Lambregts Geerard L Beets Regina G H BeetsTan

Publish Date: 2017/01/03

Volume: 42, Issue: 5, Pages: 1342-1349

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Abstract

Nineteen patients were included with DCEMRI before and/or after neoadjuvant therapy DCEMRI was performed with gadofosveset trisodium Ablavar® Lantheus Medical Imaging North Billerica Massachusetts USA Regions of interest were placed in the tumor and quantitative parameters were extracted with Olea Sphere 22 software permeability module using the extended Tofts model Semiquantitative parameters were calculated on a pixelbypixel basis Spearman rank correlation tests were used for assessment of correlation between parameters A p value ≤005 was considered statistically significantStrong positive correlations were found between mean peak enhancement and mean K trans 079 all patients p00001 083 primary staging p = 0003 and 081 restaging p = 0054 Mean washin correlated significantly with mean V p and K ep 079 and 058 respectively p00001 and p = 0009 in all patients Mean washin showed a significant correlation with mean K ep 067 p = 0033 in the primary staging group On the restaging MRI mean washin only strongly correlated with mean V p 081 p = 0054This study shows a strong correlation between quantitative and semiquantitative parameters in DCEMRI for rectal cancer Peak enhancement correlates strongly with K trans and washin showed strong correlation with V p and K ep These parameters have been reported to predict tumor aggressiveness and response in rectal cancer Therefore semiquantitative analyses might be a surrogate for quantitative analysesAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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