Correlation of Pattern of Spread and Outcomes in A

Authors: Amrutha Ramachandran Anupama Rajanbabu Kiran Gulabrao Bagul Keechilat Pavithran Dehannathparambil K Vijaykumar

Publish Date: 2017/02/02

Volume: 9, Issue: 2, Pages: 126-132

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Abstract

The purpose of this study was to correlate the pattern of spread with oncological outcomes in advanced ovarian cancer patients This is a retrospective analysis of 55 consecutive patients who had advanced epithelial ovarian cancer or primary peritoneal carcinomatosis stages 3C and 4 with primary surgical intervention as the initial modality of treatment Based on the spread of disease they were further classified into class A disease confined to the pelvis excluded class B disease extending to the lower abdomen and omentum class C diffuse smallbowel disease with or without A B or D and class D disease in the upper abdomen There were 17 patients 309 in class B 17 309 in class C and 21 382 in class D The number of patients with suboptimal cytoreduction was highest in class C six patients At the end of followup median 386 months 16 patients had no evidence of disease and 26 patients were alive with disease The 3year overall survival rates in classes B C and D were 941 525 and 933 respectively The 3year progressionfree survival rates were 558 118 and 419 respectively The rates were lowest for class C The differences in the overall survival rate p  0001 and progressionfree survival rate p = 0001 were statistically significant In advanced ovarian cancer patients the presence of disease in the smallbowel serosa and mesentery results in poorer outcomes in terms of overall and progressionfree survival The number of patients with suboptimal cytoreduction was also highest in this group

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