Journal Title
Title of Journal: FEMS Immunol Med Microbiol
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Abbravation: FEMS Immunology & Medical Microbiology
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Authors: Abe Shigeru Ohnishi Megumi Nohmi Takao Katoh Masahiro Tansho Shigeru Yamaguchi Hideyo
Publish Date: 1996/04/01
Volume: 13, Issue: 4, Pages: 311-316
Abstract
Shigeru Abe Megumi Ohnishi Takao Nohmi Masahiro Katoh Shigeru Tansho Hideyo Yamaguchi A glucocorticoid antagonist mifepristone affects antiCandida activity of murine neutrophils in the presence of prednisolone in vitro and experimental candidiasis of prednisolonetreated mice in vivo FEMS Immunology Medical Microbiology Volume 13 Issue 4 April 1996 Pages 311–316 https//doiorg/101111/j1574695X1996tb00256xThe effects of a glucocorticoidantagonist mifepristone on the suppressive action of prednisolone for antiCandida activity of murine neutrophils were examined Prednisolone suppressed inhibitory activity of neutrophils to mycelial growth of Candida albicans This suppression was cancelled in the presence of 10−7–10−6 M of mifepristone in vitro Corresponding to this in vitro action mifepristone protected prednisolonetreated mice from lethal C albicans infection in vivo These results suggest that glucocorticoidinduced vulnerability to Candida infection may be recovered or normalized by application of mifepristone
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References
citation title=Suppression of antiCandida activity of murine neutrophils by progesterone in vitro A possible predisposing factor for vaginal Candidiasis in pregnant women citation author=Nohmi T citation author=Abe S citation author=Dobashi K citation author=Tansho S citation author=Yamaguchi H citation journal title=Microbiol Immunol citation year=1995 citation volume=39 citation pages=405409
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