A stereologic evaluation of glucagonlike peptide

Authors: C Van Ginneken K Verlinden F Van Meir S Sys A Weyns

Publish Date: 2002/04/16

Volume: 205, Issue: 2, Pages: 153-157

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Abstract

Studies that investigate possible developmental changes in gastrointestinal hormones in the pig are sparse and contradictory Therefore a quantitative morphological study using stereologic methods on paraffin sections of the different small intestinal regions cranial and caudal duodenum jejunum and ileum of the developing pig second half of the gestation neonatal and weaning period has been conducted The sections were processed for GLP1immunohistochemistry During the investigated time span the volume of GLP1IR cells increased approximately 40fold in both the jejunum and ileum notwithstanding a decrease of their volume density The ileal small intestinal segment contained the highest volume density of GLP1IR cells In contrast GLP1IR cells were only occasionally encountered in the duodenum The developmentrelated changes of the investigated parameters coincide with dietary changes and the regional differences are in accordance with functional reports that point to GLP1 as a gastrointestinal hormone that ediates the ileal brake and stimulates glucosedependent pancreatic insulin secretion

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