Role of Wnt6 in limb myogenesis

Authors: Poongodi GeethaLoganathan Suresh Nimmagadda Ruijin Huang Martin Scaal Bodo Christ

Publish Date: 2005/12/21

Volume: 211, Issue: 3, Pages: 183-188

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Abstract

Cells from the ventrolateral lip of the dermomyotome at limb levels undergo epitheliomesenchymal transition and migrate as individual and undifferentiated cells into the limb buds The precursor cells are under the influence of various signaling factors in the limb Dorsal and ventral ectoderm influences various aspects of limb development In addition to our previous studies we investigated the influence of ectoderm and Wnt6 on somitic cells in the limb bud We show that in the absence of ectoderm the precursor cells never form muscle cells but differentiate into endothelial cells In addition we show that Wnt6 that is secreted from the ectoderm influences the precursor cells to form muscle even in the absence of ectoderm This indicates that Wnt6 is an ectodermal signal that induces somitederived progenitor cells to form muscle cells during limb developmentWe would like to thank Mrs L Koschny Mrs M Schüttoff and Mr G Frank for excellent technical assistance This study was supported by the Deutsche Forschungsgemeinschaft SFB592 A1 to BC MS and the European Network of Excellence MYORES BC and MS

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