Basic fibroblast growth factor expression in recur

Authors: Per CayéThomasen Knud Larsen Peter Tingsgaard Mirko Tos

Publish Date: 2003/10/09

Volume: 261, Issue: 6, Pages: 321-325

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Abstract

Various growth factors are expressed in nasal polyps and some of these have been suggested to play a role in polyp formation A potential relation between growth factor expression and polyp recurrence however is undetermined Basic fibroblast growth factor bFGF is expressed in mononuclear cells as well as in endothelial and epithelial surface and gland cells of nasal polyps To determine whether bFGF may play a role in the recurrence of nasal polyps the present study aimed at a comparison of bFGF expression in recurrent versus nonrecurrent polyps Further the expression in polyps from asthmatic patients was compared with that from nonasthmatics Thirty patients with newly diagnosed nasal polyposis were included Polypectomy was performed at entry to the longterm followup study Fifteen patients only had one polypectomy no recurrence group with a median observation time of 81 months Fifteen patients had a median of 64 polypectomies multiple recurrence group with a median observation time of 108 months Five of nine patients with asthma belonged to the nonrecurrence group and four to the recurrence group The polyp from the entrance polypectomy was examined for expression of bFGF by immunohistochemistry using a polyclonal antibody A masked semiquantification of staining intensity was performed in recurrent versus nonrecurrent polyps as well as in asthmatics versus nonasthmatics bFGF expression was seen as varying staining of the polyp surface and gland epithelium as well as of some mononuclear cells and some fibroblastlike cell profiles in the polyp stroma Vascular endothelium was labeled occasionally Semiquantification of the staining intensity showed no significant differences between recurrent and nonrecurrent polyps or between asthmatics and nonasthmatics We conclude that the level of immunohistochemical expression of bFGF in recurrent and nonrecurrent nasal polyposis is equivalent Thus the level of bFGF expression in the primary polyp can not predict a subsequent recurrence The expression of bFGF is not upregulated in patients with asthma Further studies are needed to determine a potential role of bFGF in nasal polyposis with special reference to different stages of polyp formation and growth

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