Topical furosemide versus oral steroid in preopera

Authors: Bozidar Kroflic Andrej Coer Tomislav Baudoin Livije Kalogjera

Publish Date: 2006/05/10

Volume: 263, Issue: 8, Pages: 767-771

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Abstract

The efficacy of topical nasal furosemide treatment has been shown in the protection of nasal polyp recurrence The aim of the study was to compare the effect of oral steroid as standard preoperative treatment and inhaled furosemide as alternative treatment for 7 days preoperatively in terms of subjective improvement of nasal symptoms polyp size reduction inflammation in the polyp tissue and intraoperative blood loss A group of 40 patients with nasal polyposis entered the study and they were randomly allocated to 7day preoperative treatment with either oral methylprednisolon 1 mg/kg/day or topical furosemide by inhalation 66 mmol/l solution Subjective scores of rhinosinusitis symptoms polyp scores at endoscopy and biopsy of the most superficial polyp were taken at inclusion All procedures were repeated on day 7 Intraoperative blood loss was estimated scores 0–10 by the surgeon at the operation Eosinophils mastocytes and oedema were quantified by histomorphometry Subjective symptoms and endoscopy scores did not differ significantly between the groups after the treatment although improvement of olfaction was insignificantly better in the steroid group Steroid treatment significantly reduced eosinophil count with no effect on mastocytes and oedema Furosemide treatment did not affect inflammatory cells count significantly but it has significantly reduced oedema in previously unoperated patients No difference in intraoperative bleeding was observed between the groups

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