The protective effect of erdosteine against ototox

Authors: M Tayyar Kalcioglu Ahmet Kizilay Mukaddes Gulec Erkan Karatas Mustafa Iraz Omer Akyol Mucahit Egri Orhan Ozturan

Publish Date: 2005/03/02

Volume: 262, Issue: 10, Pages: 856-863

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Abstract

The elimination of cisplatin ototoxicity is an ongoing concern This experimental study was undertaken to investigate the effect of oral erdosteine in ameliorating cisplatininduced ototoxicity Twentyeight adult female Wistar albino rats were randomly divided into four equal groups Group A received an oral carrier vehicle of the drug erdosteine with 02 ml of 09 saline Group B was administered only erdosteine per oral 10 mg/kg twice a day for 6 days Group C was injected with cisplatin intraperitoneally ip on day 0 16 mg/kg body weight once only Group D was given erdosteine per oral 10 mg/kg/day 1 day before and for 5 days consecutively after cisplatin injection 16 mg/kg ip Distortion product otoacoustic emissions DPOAEs were elicited in different frequency regions ranging from 1001 to 6299 Hz as DPgram and input/output I/O functions from the control and experimental animals All experimental animals were killed under general anesthesia on day 5 following the last otoacoustic emission measurements Prior to death blood samples were drawn for measurement of superoxide dismutase xanthine oxidase XO malondialdehyde and nitric oxide Initial DPgram and I/O function baseline measurements were similar in all groups prior to any drug administration P005 On day 5 intrasubject measurement parameters of DPgrams and I/O functions in the cisplatin group showed significant deterioration P 005 The other groups revealed no differences between their pre and posttest drug administration DPgrams and I/O functions at any test frequency P005 Comparison of the amplitudes of DPgrams and I/O functions between the cisplatin and control groups showed significant changes P 005 Biochemical studies noted an increased XO activity following cisplatin administration P 0007 The other biochemical results did not show significant differences between the study and control groups This study demonstrates that in rats erdosteine is protective for cochlear function against the disruptive effects of cisplatin as measured by DPOAEsThe authors thank Herman Jenkins MD of the Department of Otolaryngology Colorado University Denver Colorado USA for his help in the preparation of our manuscript The research was supported by the research fund of Inonu University Malatya Turkey

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