Benign prostate hyperplasia evaluation of treatme

Authors: J T Heverhagen H von TenggKobligk K T Baudendistel G Jia H Polzer H Henry A L Levine T J Rosol M V Knopp

Publish Date: 2004/06/23

Volume: 17, Issue: 1, Pages: 5-11

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Abstract

Benign prostate hyperplasia BPH is a major disease and its nonsurgical therapy a major area of interest The purpose of this study was to establish perfusion parameters in beagles with BPH using dynamic contrastenhanced DCE MRI and to investigate changes due to the effects of finasteride treatment Twelve male beagles mean age 44±09years were divided into a control and treatment group that received a daily dose of 1 mg/kg finasteride DCE MRI was carried out in a clinical scanner using a 3D spoiled gradient echo sequence prior to and during treatment 02 mmol/kg contrast agent gadoteridol was administered with an injection rate of 02 ml/s followed by a 15 ml flush of saline Contrast enhancement was evaluated by pharmacokinetic mapping of a twocompartment model with colour overlay images in addition to regional ROI analysis Quantitative parameters were defined by the amplitude of contrast enhancement A the exchange rate kep and the time to maximum signal enhancement Dynamic contrastenhanced MRI investigations of the prostate revealed two distinct zones an inner periurethral zone and an outer parenchymal zone The periurethral zone is highly vascularized whereas the parenchymal zone is moderately vascularized when compared to other parenchymal organs During treatment in the parenchymal zone the intensity of enhancement amplitude A and the time to maximum signal enhancement increased while the exchange rate kep decreased Dynamic contrastenhanced MRI of BPH reveals distinct differences between individual zones within the prostate Moreover changes during successful treatment suggest increased blood volume per volume of tissue and decreased vessel leakiness

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