A novel continuous arterial spin labeling approach

Authors: Yuguang Meng Hao Lei

Publish Date: 2008/12/05

Volume: 22, Issue: 2, Pages: 135-142

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Abstract

In the proposed method the longitudinal magnetization of brain tissue water in the imaging slice is prepared into a proper state before spinlabeling and a posttagging delay is employed after spinlabeling The method was implemented on a 47 T small animal scanner Numerical simulations and in vivo experiments were used to evaluate the performance of the method proposedWith the proposed method absolute CBF could be measured accurately from normal rat with a spinlabeling pulse as short as 400 ms and yet employing the same formula as that used in the conventional CASL perfusion imaging method for calculation The method also showed improved SNR f per unit time over the conventional CASL perfusion imaging method and the pulsed arterial spin labeling perfusion imaging method FAIRCompared to the conventional CASL perfusion imaging method the proposed method would be advantageous for CBF measurement in small animals having short vascular transit time in terms of SNR f per unit time and other benefits brought by shortened spinlabeling pulse

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