In vivo intermolecular zeroquantum coherence MR s

Authors: David Z Balla Cornelius Faber

Publish Date: 2007/09/18

Volume: 20, Issue: 4, Pages: 183-

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Abstract

The feasibility of in vivo magnetic resonance spectroscopy of the healthy rat spinal cord at 176 T using conventional methods and intermolecular zeroquantum coherence iZQC spectroscopy is explored and the performance of both approaches is comparedWellresolved in vivo spectra showing the four singlet resonances of creatine choline and Nacetyl aspartate were obtained with both approaches iZQC spectra were acquired from larger voxels but did not provide higher sensitivity or resolution in the healthy spinal cord In the presence of paramagnetic ironoxide particles the quality of in vitro spectra acquired with PRESS declined and was strongly dependent on the quality of the local shim iZQC spectra were not affected by the presence of ironoxide particles and provided narrow lines 9 Hz independent of the shimIn vivo iZQC spectroscopy of the rat spinal cord is possible The robustness in presence of local field distortions makes iZQC methods a promising alternative for the investigation of tissue containing labelled cells implants or clotted blood New application of MRS to tissue inaccessible using conventional methods may thus become possible

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