Premessenger RNA processing and its regulation a

Authors: M Soller

Publish Date: 2006/02/07

Volume: 63, Issue: 7-8, Pages: 796-819

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Abstract

The sequence of entire genomes from higher eukaryotes revealed that an average gene is very large due to the interruption of the coding sequence with large noncoding introns Introns are cotranscriptionally removed by splicing with great accuracy and fidelity although contrary to our expectations currently known signals required for premessenger RNA mRNA processing are very degenerate and redundant Furthermore the vast majority of genes are alternatively processed A large number of proteins are therefore involved in generating specificity in premRNA processing that requires a dedicated mechanisms to operate at genomic dimensions In this review I will summarize recent progress in understanding how established principles of premRNA processing extend to genomic dimensions and discuss emerging concepts in coupling of premRNA processing with other nuclear events and nuclear organization

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