Axon guidance at the central nervous system midlin

Authors: G Tear

Publish Date: 2014/02/06

Volume: 55, Issue: 11, Pages: 1365-1376

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Abstract

A key feature of the central nervous system of most higher organisms is their bilateral symmetry about the midline The specialised cells that lie at the midline have an essential role in regulating the axon guidance decisions of both neurons that project axons across the midline and those that project on one side The midline cells produce both attractive and repellent short and longrange signals to guide axonal growth The axons themselves express specific receptors that can be dynamically regulated in response to midlinederived signals In this way axons extend toward or away from the midline and those that do cross change their behaviour to respond to longitudinal signals on the contralateral side

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