Journal Title
Title of Journal: CMLS Cell Mol Life Sci
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Abbravation: Cellular and Molecular Life Sciences CMLS
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Publisher
Birkhäuser-Verlag
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Authors: B Elliott M Jasin
Publish Date: 2014/04/30
Volume: 59, Issue: 2, Pages: 373-385
Abstract
The correct repair of doublestrand breaks DSBs is essential for the genomic integrity of a cell as inappropriate repair can lead to chromosomal rearrangements such as translocations In many hematologic cancers and sarcomas translocations are the etiological factor in tumorigenesis resulting in either the deregulation of a protooncogene or the expression of a fusion protein with transforming properties Mammalian cells are able to repair DSBs by pathways involving homologous recombination and nonhomologous endjoining The analysis of translocation breakpoints in a number of cancers and the development of model translocation systems are beginning to shed light on specific DSB repair pathways responsible for the improper repair of broken chromosomes
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