Effects of high dose retinoic acid on TGFβ2 expre

Authors: Neriman Colakoglu Aysel Kukner Jale Oner M Fatih Sonmez Hakan Oner Enver Ozan

Publish Date: 2006/02/15

Volume: 36, Issue: 6-7, Pages: 413-418

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Abstract

First group of animals used as control while a single dose of 60 mg/kg alltrans retinoic acid was ingested by the mothers at day 8 of gestation before the neurulation period in group II and at day 12 of gestation after the neurulation period in group III and all embryos were sacrificed at day 18 of gestation TGFβ2 expression was detected in the capsule acini and Langerhans islets in the control group In the pancreas of group II dilatation and congestion of interlobular vessels were observed Langerhans islet structures were completely absent Moreover acinar TGFβ2 immune reactivity was not determined In group III acinar expression of TGFβ2 in acid was similar to that in the controls but their Langerhans islets TGFβ2 immune reactivity was significantly less than the controlsIn view of the present findings we suggest that TGFβ2 plays important role in pancreatic morphogenesis and administration of excess alltrans retinoic acid before neurulation inhibit TGFβ2 expression disrupted pancreatic morphogenesis particularly Langerhans islets However its administration after neurulation had less adverse affect on pancreatic organogenesis and TGFβ2 immune reactivity

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