Expression and regulation of Runx3 in mouse uterus

Authors: ZhiKun Bai Bin Guo XueChao Tian DangDang Li ShouTang Wang Hang Cao QuYuan Wang ZhanPeng Yue

Publish Date: 2013/04/10

Volume: 44, Issue: 5, Pages: 519-526

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Abstract

The aim of this study was to investigate the differential expression and regulation of Runtrelated transcription factor 3 Runx3 in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization There was a low level of the Runx3 mRNA expression in the mouse uterus on days 1–4 of pregnancy On day 5 when embryo implanted Runx3 mRNA signal was obviously observed in the stromal cells surrounding the implanting blastocyst From day 6 to 8 of pregnancy Runx3 mRNA was highly expressed in the decidual cells and mesometrial decidual beds Similarly Runx3 mRNA was strongly expressed in decidualized cells under artificial decidualization Compared with the delayed uterus a high level of Runx3 mRNA signal was detected in the uterus with activated implantation In the ovariectomized mouse uterus estrogen could induce the expression of Runx3 while progesterone had no effects These results suggest that Runx3 may play an important role during mouse implantation and decidualization Estrogen can induce the expression of Runx3 in the ovariectomized mouse uterusThis work was financially supported by National Natural Science Foundation of China 31072099 and 31101778 Research Fund for the Doctoral Program of Higher Education of China 20100061110078 and “985” Platform Construction Foundation of Jilin University

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