Journal Title
Title of Journal: Curr colorectal cancer rep
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Abbravation: Current Colorectal Cancer Reports
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Publisher
Current Science Inc.
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Authors: Brett W Doxey Scott K Kuwada
Publish Date: 2007/05/30
Volume: 3, Issue: 1, Pages: 10-15
Abstract
Clinical criteria aid in the decision to pursue genetic testing for suspected cases of hereditary nonpolyposis colon cancer HNPCC and continue to be refined Sequence analysis offers the greatest opportunity for definitive germline mutation testing however prescreening through microsatellite instability and/or immunohistochemistry offers a cost effective alternative and recent studies suggest both are complementary BRAF mutations and hMLH1 promoter methylation appear to have negative predictive value for identifying individuals with HNPCC but further studies are needed We review strategies for the evaluation of suspected HNPCC as well as emerging issues in testing
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