Journal Title
Title of Journal: Curr Colorectal Cancer Rep
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Abbravation: Current Colorectal Cancer Reports
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Authors: Kimmie Ng
Publish Date: 2014/06/27
Volume: 10, Issue: 3, Pages: 339-345
Abstract
Vitamin D insufficiency is highly prevalent in the US particularly among colorectal cancer CRC patients These low levels of vitamin D are concerning given increasing evidence that vitamin D may have health benefits beyond skeletal outcomes Prospective observational studies suggest that higher vitamin D levels are associated with lower risk of incident CRC and improved survival for patients with established CRC and randomized clinical trials are urgently needed to establish causality Moreover there remains a great need to improve prognosis for patients with CRC and investigating vitamin D as a potential therapy is an attractive option in regards to safety and cost particularly in this era of expensive and often toxic antineoplastic agents In this review the evidence regarding the activity of vitamin D in CRC will be summarized spanning preclinical epidemiological and clinical studies and future research directions will be discussed
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