Epigenetic and Immune Regulation of Colorectal Can

Authors: Amy V Paschall Kebin Liu

Publish Date: 2015/10/10

Volume: 11, Issue: 6, Pages: 414-421

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Abstract

Colorectal cancer stem cells CSCs were initially considered to be a subset of undifferentiated tumor cells with welldefined phenotypic and molecular markers However emerging evidence indicates instead that colorectal CSCs are heterogeneous subsets of tumor cells that are continuously reshaped by the dynamic interactions between genetic epigenetic and immune factors in the tumor microenvironment Thus the colorectal CSC phenotypes and responsiveness to therapy may not only be a tumor cellintrinsic feature but also depend on tumorextrinsic microenvironmental factors Furthermore emerging evidence also implicates colorectal CSCs in potential immune evasion Therefore understanding how colorectal CSCintrinsic mechanisms cooperate with the extrinsic microenvironmental factors to dynamically shape colorectal CSC resistance to chemotherapy and immunotherapy holds great promise for development of targeted CSC therapies of advanced human CRC

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