Journal Title
Title of Journal: Curr Allergy Asthma Rep
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Abbravation: Current Allergy and Asthma Reports
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Publisher
Current Science Inc.
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Authors: H William Kelly
Publish Date: 2007/06/22
Volume: 7, Issue: 4, Pages: 310-314
Abstract
The purpose of this review is to determine whether the proinflammatory actions identified in vitro for Salbuterol provide a clinically significant therapeutic advantage for levalbuterol over racemic albuterol Clinical trials evaluating the bronchodilation in chronic and acute asthma provide conflicting evidence Older trials suggested an advantage for levalbuterol however the newer trials have failed to confirm those advantages Although Salbuterol produces increased bronchial hyperresponsiveness in vitro and in animal models this has not been consistently confirmed in clinical trials however the heterogeneity of the trials precludes definitive conclusions Current clinical trials do not provide evidence of a substantial advantage of levalbuterol over racemic albuterol although the data are insufficient to determine whether subsets of the patient population might benefit from single isomer therapy
Keywords:
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