Journal Title
Title of Journal: Curr Allergy Asthma Rep
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Abbravation: Current Allergy and Asthma Reports
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Authors: Anna R Smith George Knaysi Jeffrey M Wilson Julia A Wisniewski
Publish Date: 2017/02/09
Volume: 17, Issue: 1, Pages: 6-
Abstract
Defects in skin barrier function in infancy set the stage for the development of atopic dermatitis AD and allergy Both genetic and environmental factors can contribute to damage of the stratum corneum SC with activation of specific protease enzymes under high pH conditions playing a key role Immune cells and mediators in the dermis and epidermis impair SC repair mechanisms and support allergy development In barrierdisrupted skin type 2 innate lymphoid cells ILC2s mast cells MCs and basophils have been shown to promote AD and pathogenic Th2 responses in murine modelsSkin barrier disruption favors induction of systemic Th2associated inflammatory pathways A better understanding of the ontogeny and regulation of these complex networks in infant skin is needed to guide future strategies for allergy treatment and prevention
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