Journal Title
Title of Journal: Curr Allergy Asthma Rep
|
Abbravation: Current Allergy and Asthma Reports
|
|
|
|
|
|
|
|
Authors: Clinton B Mathias
Publish Date: 2014/12/11
Volume: 15, Issue: 2, Pages: 500-
Abstract
Asthma is an immunemediated disease of the airways characterized by reversible airway obstruction bronchial eosinophilic inflammation and airway hyperresponsiveness AHR The immune dysregulation in asthma has been attributed to the involvement of diverse immune cells that contribute to the immunopathology of the disease Natural killer NK cells play critical roles in host defense against viruses and various cancers Accumulating evidence demonstrates additional important roles for these cells in T cell priming dendritic cell maturation and the development of inflammation all of which have the potential to enhance or dampen allergic responses The ability of NK cells to produce Th2type cytokines and their pivotal role in combating respiratory infections which cause airway dysfunction in asthmatics further suggest that they may directly contribute to the immunopathogenesis of allergic airway disease In this review we examine emerging evidence and discuss the putative roles of NK cells in the sensitization progression and resolution of asthma
Keywords:
.
|
Other Papers In This Journal:
|