T cell tolerance to the skin a central role for c

Authors: Prisca Schuler Emmanuel Contassot Bertrand Huard

Publish Date: 2007/03/17

Volume: 29, Issue: 1, Pages: 59-64

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Abstract

T cell tolerance to selfantigens is believed to be achieved in a twostep process The first step called central tolerance takes place in the thymus The second step takes place outside the thymus in secondary lymphoid organs One may ask why two mechanisms are needed to insure T cell tolerance These two mechanisms share redundant functions and dysfunctions leading to T cellmediated autoimmune syndromes By reviewing the literature on relevant animal models for T cell tolerance and our own recent findings we are providing evidences that only central tolerance is acting for the skin

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