Journal Title
Title of Journal: Semin Immunopathol
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Abbravation: Seminars in Immunopathology
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Publisher
Springer-Verlag
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Authors: Jan Storek Michelle Geddes Faisal Khan Bertrand Huard Claudine Helg Yves Chalandon Jakob Passweg Eddy Roosnek
Publish Date: 2008/10/24
Volume: 30, Issue: 4, Pages: 425-
Abstract
Hematopoietic stem cell transplantation is associated with a severe immune deficiency As a result the patient is at high risk of infections Innate immunity including epithelial barriers monocytes granulocytes and NK cells recovers within weeks after transplantation By contrast adaptive immunity recovers much slower B and Tcell counts normalize during the first months after transplantation but in particular Tcell immunity may remain impaired for years During the last decade much of the underlying mechanisms have been identified These insights may provide new therapies to accelerate recovery
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