Authors: Rebecca G Baker Gary A Koretzky
Publish Date: 2008/09/16
Volume: 42, Issue: 1-3, Pages: 132-144
Abstract
Integrins are cell surface heterodimers that bind adhesion molecules expressed on other cells or in the extracellular matrix Integrinmediated interactions are critical for T cell development in the thymus migration of T cells in the periphery and induction of T cell effector functions In resting T cells integrins are maintained in a low affinity state Engagement of the T cell receptor or chemokine receptors increases integrin affinity enabling integrins to bind their ligands and initiate a signaling cascade resulting in altered cell morphology and motility Our laboratory is interested how adapter proteins mediators of intracellular signal transduction regulate both signals from the T cell receptor to integrins insideout signaling and outsidein signals from integrins into the cell
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