Journal Title
Title of Journal: Curr Neurol Neurosci Rep
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Abbravation: Current Neurology and Neuroscience Reports
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Publisher
Current Science Inc.
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Authors: Joseph Scafidi Vittorio Gallo
Publish Date: 2008/03/29
Volume: 8, Issue: 2, Pages: 130-138
Abstract
This article summarizes recent insights into perinatal hypoxicischemic brain injury in the neonate Before effective treatments can be offered diagnosis timing and an understanding of the pathogenesis are imperative The analysis of appropriate animal models is also summarized in this review These models have provided interesting evidence that after hypoxia ischemia progenitor cells in the postnatal brain are stimulated to generate new neurons and oligodendrocytes The role of these newly generated cells is unclear and mechanisms of migration and survival are currently being elucidated A discussion of more recent imaging techniques such as diffusion tensor imaging is provided This allows for improved understanding of the microstructural organization of white matter and how this is altered by hypoxicischemic injury Neuroprotection with hypothermia is now occurring in fullterm neonates that meet clinical criteria however specific therapies such as inhibition of nonNmethylDaspartate receptors may offer improved outcomes by targeting specific pathways and populations of cells
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